Production of pellets from wet masses containing olanzapine by extrusion and spheronization
In this study pellets were produced from wet masses containing olanzapine by extrusion and spheronization. This technique is used worldwide to create multiparticulate solid dosage forms. The extrudability of wet masses containing olanzapine into pellets, was tested. First pellets were manufactured containing only microcrystalline cellulose (MCC), tricalcium phosphate (TCP) and water. In the second part of the study, olanzapine was added as active pharmaceutical ingredient. In both parts of the study, pellets were manufactured with different formulations of excipients.
Meer lezen